We like to think that no molecule, no matter its structural type, is out of the reach of chemical synthesis. The real question, however, is how elegantly and efficiently can we synthesize such complex molecules, and it is here that the synthetic chemists have to concentrate their efforts the most. Chemical synthesis is an exceedingly exciting, challenging, and fulfilling discipline, one that will always appeal to those talented youngsters who are destined to shape it further and ensure the continuation of its proud tradition as they strive to equal or even surpass Nature at her own game.

K. C. Nicolaou, Joys of Molecules. 1. Campaigns in Total Synthesis

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